This week, we welcome Michael Hochberg
Evolution and Environment Shape Cancer Across Species
Evolutionary theory explains why metazoan species are largely protected against the negative fitness effects of cancers. Nevertheless, cancer is observed across a range of species and sometimes at high prevalence. I present a simple model showing how life history traits (e.g., body size) are expected to co-evolve with anti-cancer mechanisms. The insights of this model form the basis for understanding cancer incidence and resistance mechanisms in different species and across different human tissues.